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KMID : 1134820180470040387
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 4 p.387 ~ p.394
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Inhibitory Properties of Gracilaria textorii Ethanol Extract on the Inflammatory Immune Response
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Kim Min-Ji
Kim Koth-Bong-Woo-Ri
Jang Mi-Ran
Im Moo-Hyeog
Cho Young-Je
Ahn Dong-Hyun
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Abstract
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In this study, the anti-inflammatory effects of ethanol extract from the marine red algal genus Gracilaria textorii were tested against lipopolysaccharide (LPS)-induced activation in RAW 264.7 cells and croton oil-induced ear edema in mice. Both nitric oxide and pro-inflammatory cytokine production in RAW 264.7 cells, which had been stimulated by LPS, were significantly suppressed by G. textorii ethanol extract (GTEE) treatment in a dose-dependent manner. In addition, expression levels of NF-κB signaling-related proteins (NF-κB, iNOS, and COX-2) and the phosphorylation of MAPK family (p38, JNK, and ERK) were reduced by GTEE. Moreover, GTEE administration in a croton oil-induced ear inflammatory murine model markedly attenuated severe local ear edema. Our results clearly indicate that GTEE can be a potential candidate for novel therapeutic natural agents in the inflammatory immune response.
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KEYWORD
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Gracilaria textorii, anti-inflammatory activity, nuclear factor-kappa B, mitogen activated protein kinases
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